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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBK1
All Species:
23.03
Human Site:
Y435
Identified Species:
46.06
UniProt:
Q9UHD2
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHD2
NP_037386.1
729
83642
Y435
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
Chimpanzee
Pan troglodytes
XP_509194
729
83592
Y435
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
Rhesus Macaque
Macaca mulatta
XP_001116917
729
83571
Y435
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
Dog
Lupus familis
XP_538266
729
83709
Y435
I
A
S
T
L
Q
L
Y
Q
E
L
M
R
K
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUN2
729
83406
Y435
T
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
Rat
Rattus norvegicus
Q9QY78
757
86848
L440
V
W
H
S
I
Q
T
L
K
E
D
C
N
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507889
713
81825
Y419
V
A
S
S
L
L
L
Y
Q
E
L
M
R
K
G
Chicken
Gallus gallus
Q5ZJB4
759
86125
I434
D
S
K
I
Q
L
P
I
P
Q
L
R
K
V
W
Frog
Xenopus laevis
Q6DFJ6
725
83252
V435
I
A
A
S
L
L
L
V
L
D
L
M
R
K
G
Zebra Danio
Brachydanio rerio
Q4G3H4
758
87129
L421
E
T
K
T
Q
L
P
L
S
T
L
K
K
V
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VEZ5
751
86354
S459
K
I
P
E
P
I
L
S
I
L
S
R
K
F
I
Honey Bee
Apis mellifera
XP_396937
720
81974
L439
R
R
I
D
K
L
V
L
C
S
K
L
S
Q
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99
96.7
N.A.
94
22
N.A.
88.1
20.1
73.3
20.9
N.A.
20.5
38
N.A.
N.A.
Protein Similarity:
100
99.8
99.8
98.9
N.A.
97.6
42.5
N.A.
94.6
39.9
86.8
41.8
N.A.
39.5
57.7
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
86.6
13.3
66.6
20
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
40
N.A.
100
33.3
86.6
26.6
N.A.
20
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
59
9
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% C
% Asp:
9
0
0
9
0
0
0
0
0
9
9
0
0
0
9
% D
% Glu:
9
0
0
9
0
0
0
0
0
59
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
59
% G
% His:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
42
9
9
9
9
9
0
9
9
0
0
0
0
0
9
% I
% Lys:
9
0
17
0
9
0
0
0
9
0
9
9
25
59
0
% K
% Leu:
0
0
0
0
59
75
67
25
9
9
75
9
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
59
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
0
0
9
0
9
0
17
0
9
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
17
17
0
0
50
9
0
0
0
9
0
% Q
% Arg:
9
9
0
0
0
0
0
0
0
0
0
17
59
9
0
% R
% Ser:
0
9
50
25
0
0
0
9
9
9
9
0
9
0
0
% S
% Thr:
9
9
0
50
0
0
9
0
0
9
0
0
0
0
0
% T
% Val:
17
0
0
0
0
0
9
9
0
0
0
0
0
17
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
17
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _